In Silico Analysis of Honeybee Venom Protein Interaction with Wild Type and Mutant (A82V + P375S) Ebola Virus Spike Protein

Venom from different organisms was used in ancient times to treat a wide range of diseases, and combat variety enveloped non-enveloped viruses. The aim this silico research investigate the impact honeybee venom proteins peptides against Ebola virus. In current study, online offline tools were used. RaptorX (protein 3D modeling) PatchDock (protein–protein docking) as tools, while Chimera LigPlot + v2.1 for visualizing protein–protein interactions. We screened nine normal virus spike protein found that melittin, MCD phospholipase A2 showed strong interaction. then these mutated strains enzyme According findings, may be an effective source antiviral therapy deadly Although potency has been recorded previously, is first analysis viral its more lethal mutant strain.